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Serum

We Recommend

Full Ingredients

Clinical Results

Key Benefits

Proven Results

Credentials

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How to use

  1. Fill the dropper and apply directly to edges, hairline, and scalp.
  2. Massage with fingertips.
  3. Repeat if necessary. Do not rinse. Style hair as usual.
  4. Use daily for best results. Can be used on dry or damp hair.

Helps preserve your natural pigment over time by supporting the health of pigment-producing cells in the hair follicle.

What it does

Delivers research-inspired, biomimetic compounds to the scalp, designed to help melanocytes keep doing what they're meant to do.

Why it's safe

A non-invasive, cosmetic formula developed from decades of cellular research. No dyes, no color additives, just topical support for your biology.

Try the grey hair simulator
Rosemary

Rosemary

Helps defend hair color by fighting oxidative stress, one of the key drivers linked to premature greying. Rosemary is a botanical rich in antioxidant compounds and aromatic actives. In hair biology terms, lowering oxidative stress supports the health of pigment-producing cells and the follicle environment where melanin is made. As a bonus, rosemary is widely used for scalp comfort and a fresher, healthier-looking hair routine.

Rice Bran Extract

Rice Bran Extract

Supports lasting, vibrant-looking color by nourishing the follicle with antioxidant lipids that protect pigment pathways. Rice bran extract is derived from the nutrient-dense outer layer of rice and naturally contains vitamin E-type compounds and other protective phytochemicals. Those antioxidants help shield the follicle from daily stressors that can accelerate pigment decline. It also supports softness and shine, so hair looks healthier while you support color longevity.

Tyrosine

Tyrosine

Supports your hair’s natural pigment by supplying a key building block used to make melanin. Tyrosine is an amino acid that sits at the start of the melanin production pathway. When pigment cells have the raw materials they need, they are better positioned to keep producing color consistently over time. It also supports overall hair vitality because it is part of the protein chemistry behind strong hair.

Neostemix

Neostemix

Designed to protect pigment-producing cells so they can keep making color for longer. This is Prologue’s in-house biomimetic peptide blend, created to support the survival and resilience of melanocytes, the cells that produce melanin in the follicle. When these cells stay healthier under stress, the follicle is better able to maintain its pigment program. The result is a science-led approach to preserving the biology of color, not just covering greys.

PTP-20

PTP-20

Supports natural-looking hair color by helping activate the biological signals involved in pigmentation. PTP-20 is a biomimetic peptide designed to communicate with pigment-related pathways in the follicle. In simple terms, it helps “remind” pigment cells to keep doing their job, supporting melanin output and a more even-looking shade.

Caffeine

Caffeine

Supports pigmentation by energizing the follicle environment and reducing stress signals that can interfere with healthy color. Caffeine is a well-known scalp active that stimulates and supports the look of stronger hair at the root. In the context of greying, a healthier, better-supported follicle environment makes it easier for pigment cells to stay active and consistent. It is also loved for the “wake-up” feel it brings to a daily routine.

Luteolin

Luteolin

Helps protect against premature greying by defending pigment biology with strong antioxidant and anti-inflammatory support. Luteolin is a plant-derived flavonoid studied for its ability to calm damaging stress pathways that can disrupt pigment maintenance in follicles. By reducing oxidative and inflammatory pressure, luteolin supports the signals that keep pigment stem cells and melanocytes functioning. It is a smart, modern choice when the goal is keeping hair color stable over time.

Vitamins

Vitamins

Supports long-term color by feeding the follicle with essentials linked to healthy pigment production and stress defense. This blend focuses heavily on B-vitamins and antioxidants, nutrients commonly associated with hair vitality and pigmentation support. In practical terms, they help maintain healthy cell metabolism in the follicle and provide antioxidant backup that can protect pigment pathways from daily wear and tear. You get both beauty benefits (stronger-looking, healthier-feeling hair) and biology support for keeping your natural shade.

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Application

How to use

  1. Fill the dropper and apply directly to edges, hairline, and scalp.
  2. Massage with fingertips.
  3. Repeat if necessary. Do not rinse. Style hair as usual.
  4. Use daily for best results. Can be used on dry or damp hair.
Best for

Helps preserve your natural pigment over time by supporting the health of pigment-producing cells in the hair follicle.

What it does

Delivers research-inspired, biomimetic compounds to the scalp, designed to help melanocytes keep doing what they're meant to do.

Why it's safe

A non-invasive, cosmetic formula developed from decades of cellular research. No dyes, no color additives, just topical support for your biology.

Try the grey hair simulator
Key active ingredients
Rosemary

Rosemary

Helps defend hair color by fighting oxidative stress, one of the key drivers linked to premature greying. Rosemary is a botanical rich in antioxidant compounds and aromatic actives. In hair biology terms, lowering oxidative stress supports the health of pigment-producing cells and the follicle environment where melanin is made. As a bonus, rosemary is widely used for scalp comfort and a fresher, healthier-looking hair routine.

Rice Bran Extract

Rice Bran Extract

Supports lasting, vibrant-looking color by nourishing the follicle with antioxidant lipids that protect pigment pathways. Rice bran extract is derived from the nutrient-dense outer layer of rice and naturally contains vitamin E-type compounds and other protective phytochemicals. Those antioxidants help shield the follicle from daily stressors that can accelerate pigment decline. It also supports softness and shine, so hair looks healthier while you support color longevity.

Tyrosine

Tyrosine

Supports your hair’s natural pigment by supplying a key building block used to make melanin. Tyrosine is an amino acid that sits at the start of the melanin production pathway. When pigment cells have the raw materials they need, they are better positioned to keep producing color consistently over time. It also supports overall hair vitality because it is part of the protein chemistry behind strong hair.

Neostemix

Neostemix

Designed to protect pigment-producing cells so they can keep making color for longer. This is Prologue’s in-house biomimetic peptide blend, created to support the survival and resilience of melanocytes, the cells that produce melanin in the follicle. When these cells stay healthier under stress, the follicle is better able to maintain its pigment program. The result is a science-led approach to preserving the biology of color, not just covering greys.

PTP-20

PTP-20

Supports natural-looking hair color by helping activate the biological signals involved in pigmentation. PTP-20 is a biomimetic peptide designed to communicate with pigment-related pathways in the follicle. In simple terms, it helps “remind” pigment cells to keep doing their job, supporting melanin output and a more even-looking shade.

Caffeine

Caffeine

Supports pigmentation by energizing the follicle environment and reducing stress signals that can interfere with healthy color. Caffeine is a well-known scalp active that stimulates and supports the look of stronger hair at the root. In the context of greying, a healthier, better-supported follicle environment makes it easier for pigment cells to stay active and consistent. It is also loved for the “wake-up” feel it brings to a daily routine.

Luteolin

Luteolin

Helps protect against premature greying by defending pigment biology with strong antioxidant and anti-inflammatory support. Luteolin is a plant-derived flavonoid studied for its ability to calm damaging stress pathways that can disrupt pigment maintenance in follicles. By reducing oxidative and inflammatory pressure, luteolin supports the signals that keep pigment stem cells and melanocytes functioning. It is a smart, modern choice when the goal is keeping hair color stable over time.

Vitamins

Vitamins

Supports long-term color by feeding the follicle with essentials linked to healthy pigment production and stress defense. This blend focuses heavily on B-vitamins and antioxidants, nutrients commonly associated with hair vitality and pigmentation support. In practical terms, they help maintain healthy cell metabolism in the follicle and provide antioxidant backup that can protect pigment pathways from daily wear and tear. You get both beauty benefits (stronger-looking, healthier-feeling hair) and biology support for keeping your natural shade.

Sustainability

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Lorem ipsum

Fusce eget lacus in ante efficitur consectetur. Fusce luctus dignissim ipsum, sit amet venenatis eros efficitur ac. Mauris ornare mauris sit amet euismod placerat. Donec ut neque id magna imperdiet lobortis non ut tellus. Aliquam gravida tincidunt sem, in tempus est elementum tempus. Phasellus at dui eu urna ultrices volutpat. Maecenas at orci nec ligula sagittis hendrerit vitae et risus.

What to expect over time

How results build with consistent use

The Foundation

Week 1-4

The Foundation

NeoStemix begins supporting stem cell activity. The work is happening, just not visibly yet.

The Activation

Week 4-8

The Activation

Stem cells may begin responding. New strands from treated follicles may show early pigment return.

The Result

Week 8-16

The Result

New growth may show measurably stronger pigmentation. Color returns as new hair grows from the follicle.

The Maintenance

Month 6+

The Maintenance

Regular use supports the conditions for natural pigment production. Built for the long term.

A system designed to support pigment over time

Cleanse

Chapter 01

Cleanse

Gently cleanses while creating the conditions for consistent use across the system.

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Preserve

Chapter 02

Preserve

Gently cleanses while creating the conditions for consistent use across the system.

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Conditions

Chapter 03

Conditions

Locks in hydration and manageability to support long-term adherence.

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FAQ

FAQ

How does Prologue actually prevent gray hair?

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How does Prologue actually prevent gray hair?

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Why does hair turn gray in the first place?

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Why does hair turn gray in the first place?

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Is Prologue safe to use?

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Is Prologue safe to use?

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Do I need to stop coloring my hair?

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Do I need to stop coloring my hair?

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Scientific references

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